SrasV1, Main, Exploration, bibRecord, 003675

Inhibition of SARS-CoV gene expression by adenovirus-delivered small hairpin RNA.

Identifieur interne : 003675 ( Main/Exploration ); précédent : 003674; suivant : 003676

Inhibition of SARS-CoV gene expression by adenovirus-delivered small hairpin RNA.

Auteurs : Xue Zhang [République populaire de Chine] ; Kailang Wu ; Xin Yue ; Ying Zhu ; Jianguo Wu

Source :

Intervirology [ 0300-5526 ] ; 2007.

RBID : pubmed:17139181

Descripteurs français

KwdFr :
- ARN antisens (génétique), ARN viral (analyse), Adenoviridae (génétique), Animaux, Expression des gènes, Gènes rapporteurs, Humains, Lignée cellulaire, Luciferases (analyse), Protéines de l'enveloppe virale (biosynthèse), Protéines de l'enveloppe virale (génétique), Protéines nucléocapside (biosynthèse), Protéines nucléocapside (génétique), Protéines virales (analyse), RT-PCR, Réplication virale, Technique de Western, Vecteurs génétiques, Virus du SRAS (génétique), Virus du SRAS (physiologie).
MESH :
- analyse : ARN viral, Luciferases, Protéines virales.
- biosynthèse : Protéines de l'enveloppe virale, Protéines nucléocapside.
- génétique : ARN antisens, Adenoviridae, Protéines de l'enveloppe virale, Protéines nucléocapside, Virus du SRAS.
- physiologie : Virus du SRAS.
- Animaux, Expression des gènes, Gènes rapporteurs, Humains, Lignée cellulaire, RT-PCR, Réplication virale, Technique de Western, Vecteurs génétiques.

English descriptors

KwdEn :
- Adenoviridae (genetics), Animals, Blotting, Western, Cell Line, Chlorocebus aethiops, Gene Expression, Genes, Reporter, Genetic Vectors, Humans, Luciferases (analysis), Nucleocapsid Proteins (biosynthesis), Nucleocapsid Proteins (genetics), RNA, Antisense (genetics), RNA, Viral (analysis), Reverse Transcriptase Polymerase Chain Reaction, SARS Virus (genetics), SARS Virus (physiology), Viral Envelope Proteins (biosynthesis), Viral Envelope Proteins (genetics), Viral Proteins (analysis), Virus Replication.
MESH :
- chemical , analysis : Luciferases, RNA, Viral, Viral Proteins.
- chemical , biosynthesis : Nucleocapsid Proteins, Viral Envelope Proteins.
- genetics : Adenoviridae, Nucleocapsid Proteins, RNA, Antisense, SARS Virus, Viral Envelope Proteins.
- physiology : SARS Virus.
- Animals, Blotting, Western, Cell Line, Chlorocebus aethiops, Gene Expression, Genes, Reporter, Genetic Vectors, Humans, Reverse Transcriptase Polymerase Chain Reaction, Virus Replication.

Abstract

Severe acute respiratory syndrome (SARS) is a highly contagious and lethal disease caused by a new type of coronavirus, SARS-associated coronavirus (SARS-CoV). Currently, there is no efficient treatment and prevention for this disease. We constructed recombinant adenoviral vectors that can express shRNAs, which inhibited the expression of SARS-CoV genes effectively in mammalian cells.

DOI: 10.1159/000097391
PubMed: 17139181

Affiliations:

Le document en format XML

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<author><name sortKey="Zhu, Ying" sort="Zhu, Ying" uniqKey="Zhu Y" first="Ying" last="Zhu">Ying Zhu</name>
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<term>Chlorocebus aethiops</term>
<term>Gene Expression</term>
<term>Genes, Reporter</term>
<term>Genetic Vectors</term>
<term>Humans</term>
<term>Luciferases (analysis)</term>
<term>Nucleocapsid Proteins (biosynthesis)</term>
<term>Nucleocapsid Proteins (genetics)</term>
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<term>RNA, Viral (analysis)</term>
<term>Reverse Transcriptase Polymerase Chain Reaction</term>
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<term>SARS Virus (physiology)</term>
<term>Viral Envelope Proteins (biosynthesis)</term>
<term>Viral Envelope Proteins (genetics)</term>
<term>Viral Proteins (analysis)</term>
<term>Virus Replication</term>
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<term>Virus du SRAS (physiologie)</term>
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<front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) is a highly contagious and lethal disease caused by a new type of coronavirus, SARS-associated coronavirus (SARS-CoV). Currently, there is no efficient treatment and prevention for this disease. We constructed recombinant adenoviral vectors that can express shRNAs, which inhibited the expression of SARS-CoV genes effectively in mammalian cells.</div>
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Inhibition of SARS-CoV gene expression by adenovirus-delivered small hairpin RNA.

Inhibition of SARS-CoV gene expression by adenovirus-delivered small hairpin RNA.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

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